Washington was from the last generation of black American leaders born into slavery and became the leading voice of the former slaves and their descendants, who were newly oppressed by disfranchisement and the Jim Crow discriminatory laws enacted in the post-Reconstruction Southern states in the late 19th and early 20th centuries. In 1895 his Atlanta compromise called for avoiding confrontation over segregation and instead putting more reliance on long-term educational and economic advancement in the black community.

His base was the Tuskegee Institute, a historically black college in Alabama. As lynchings in the South reached a peak in 1895, Washington gave a speech in Atlanta that made him nationally famous. The speech called for black progress through education and entrepreneurship. His message was that it was not the time to challenge Jim Crow segregation and the disfranchisement of black voters in the South. Washington mobilized a nationwide coalition of middle-class blacks, church leaders, and white philanthropists and politicians, with a long-term goal of building the community's economic strength and pride by a focus on self-help and schooling. Secretly, he supported court challenges to segregation. Black militants in the North, led by W. E. B. Du Bois, at first supported the Atlanta compromise but after 1909 they set up the NAACP and tried with little success to challenge Washington's political machine for leadership in the black community. Decades after Washington's death in 1915, the Civil Rights movement generally moved away from his policies to take the more militant NAACP approach.

Booker T. Washington mastered the nuances of the political arena in the late 19th century which enabled him to manipulate the media, raise money, strategize, network, pressure, reward friends and distribute funds while punishing those who opposed his plans for uplifting blacks. His long-term goal was to end the disfranchisement of the vast majority of African Americans living in southern states, where most of the millions of black Americans still lived.