Nicholas Fiveboroughs is a Sicko, someone that takes on others' illnesses. In a city where diseases can be transferred, the rich buy longer lives without pain, and the poor get a short life of constant sickness. Maybe it was fate, or maybe someone is looking out for him, but after Nicholas barely survives his latest affliction, he gets the chance to try and change things. To finally stop the whole disease transfer network.

Tensions escalate as Nicholas infiltrates a higher society he doesn't understand, and starts to fall for the very person he needs to manipulate to be successful. And between run-ins with a talking animal and genetically modified humans, the world around him just keeps getting stranger. Can Nicholas tear down the disease transfer architecture? And can he do it without losing his own humanity along the way?