"An important and remarkably readable book, simultaneously broad, deep, and concise, offers the most comprehensive guidance I have seen for navigating the challenge of treating this population. It reflects not just evidence-based treatment, but a humane, integrative stance that invites clinicians to think across the biopsychosocial spectrum about this most vexing clinical problem. There is no other resource quite like it."

-David Mintz, MD, Director of Psychiatric Education at the Austen Riggs Center and author of Psychodynamic Psychopharmacology

"Distills an astounding amount of information into 48 clearly-written chapters, each of which is loaded with terrific and very practical advice."

-David Osser, MD, Associate Professor of Psychiatry at Harvard Medical School, author of Psychopharmacology Algorithms

"A thoughtful, scholarly, and reader-friendly summary of depression. This book will be a source of pragmatic insight and wisdom for any clinician who wrestles with the challenge of depressed patients who respond suboptimally to traditional antidepressant medications."

-Joseph F. Goldberg, MD, Clinical Professor of Psychiatry, Icahn School of Medicine, Deputy Editor-in-Chief, The Journal of Clinical Psychiatry, author of Practical Psychopharmacology

"A clear and concise survey of practical approaches to resistant depression, including both psychotherapy and medications, for busy clinicians."

-Conrad Swartz, MD, PhD, Professor Emeritus, Southern Illinois University, and author of Psychotic Depression

"Aiken proves himself to be the premier translator of clinical psychiatry research into pragmatic, clear, clinical advice for psychiatric providers. I intend on making sure all of my PMHNP students leave training with a copy, knowing it will be well used in their practice for years to come."

- Andrew Penn, MS, PMHNP, Professor, University of California, San Francisco, School of Nursing