The Sweet Tone Tots is about a brother (Melvin) and sister (Mary) who share a love for music, particularly jazz. They developed an interest in jazz from their parents. Growing up, their home is filled with the sounds of musicians such as Miles Davis, Billie Holiday, and Christian McBride, to name a few. Each day, jazz could always be heard throughout their house.

When it's time for the kids to go to sleep for the night, something magical happens. Every night, the kids seem to have the same dream: Their small backyard clubhouse transforms into Sweet Tones Jazz Club House to entertain their neighborhood friends. Joining them on stage are a few of their best friends--Jacqueline, Charles, and Louise. The five friends become amazing jazz artists known as the Sweet Tone Tots, the greatest kids' jazz band in the world. They each have the ability to play multiple instruments. The jazz club is the talk of the neighborhood, and the Sweet Tone Tots are having the time of their lives playing for their friends.