The Adventures of Rosie and Blue follows two sisters, Rosie and Blue, when they suddenly get lost and have to figure out how to make it back home. Rosie and Blue are very different from each other, they are almost complete opposites. Rosie is a friendly, happy dog, and she is not scared of anything. Blue is the opposite; she is a very anxious, shy girl, and because she fears everything, she can be reactive. Even though they are so different, they are both very deserving of love, care and safety and they make sure they give these things to each other. In their journey, they figure out how to help one another with their different emotions and needs. They both love each other very much and they will always find ways to help and care for each other, even in this scary situation they find themselves in. Rosie and Blue meet other characters along the way that will make them feel all sorts of things and teach them a few things about life, emotions and what it means to show up for someone.